Hypertension Clinical Trials

    Cutting-Edge Research

    The Hypertension Clinic at SIU Medicine, led by world-renowned expert Dr. John Flack, is conducting cutting-edge research to better treat high blood pressure. We are currently participating in national studies to explore new treatment options, including medications and one-time, device-based treatments. We also conduct local studies to better understand high blood pressure and adapt care based on individual health measures.

    Hypertension is the leading cause of heart disease. Therefore, lowering blood pressure is crucial in our mission to promote patient health and well-being. These studies provide patients with access to new, experimental treatment options that could help them. While specific benefits are unknown and may vary, participants have the opportunity to:

    • Potentially lower their blood pressure.
    • Potentially reduce the need for blood pressure medications.
    • Receive study-related care at no cost.
    • Contribute to the advancement of medical research.

    Participate in a Clinical Trial

    • The information you provide in the recruitment survey may be used to contact you if you qualify to participate in this study.
    • Your information will be retained in a confidential, secure database.
    • At any time, you can request to have your information removed from our database by contacting the SIU hypertension study team at 217-545-7511 or bpresearch@siumed.edu.

     

     

    Current Clinical Trials

    AstraZeneca BaxHTN: A Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess the Efficacy and Safety of Baxdrostat in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypert

    The purpose of this clinical trial is to trial is to learn more about a new, investigational, once daily medication, called baxdrostat, and its ability to lower blood pressure in individuals not responding to their current treatment.

    Eligible patients include those who currently have a diagnosis of high blood pressure, despite currently taking anti-hypertensive medications.

    HyPhen: Title-Hypertension Phenotype Study

    This is a local research study to relate heart health and various components found in your body (body fat, sodium, etc.) to high blood pressure during pregnancy, and those with apparently normal blood pressure.

    Eligible participants include those with high blood pressure, those receiving treatment for their high blood pressure, women who had high blood pressure during pregnancy, and those with apparently normal blood pressure.

    Mineralys (MLS-101-202): A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, PARALLEL ARM, MULTI-CENTER, PHASE 2 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LORUNDROSTAT IN SUBJECTS WITH UNCONTROLLED HYPERTENSION ON A STANDARDIZED MEDICATION REGIMEN

    The purpose of this clinical trial is to assess the blood pressure lowering effects of lorundrostat, taken once daily, in patients with high blood pressure.

    Eligible patients include those who currently have a diagnosis of high blood pressure, despite having taken or are currently taking anti-hypertensive medications.

    Mineralys MLS-101-301 A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, PARALLEL ARM, MULTICENTER PHASE 3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LORUNDROSTAT IN SUBJECTS WITH UNCONTROLLED AND RESISTANT HYPERTENSION

    The purpose of this clinical trial is to assess the blood pressure lowering effects of lorundrostat, taken once daily, in patients with high blood pressure.

    Eligible patients include those who currently have a diagnosis of high blood pressure, despite having taken or are currently taking anti-hypertensive medications.

    RADIANCE Continued Access Protocol (CAP): A study of the ReCor Medical Paradise System in Clinical Hypertension

    The purpose of this clinical trial is to find out if a medical device called the Paradise Renal Denervation System can lower blood pressure in patients who have hypertension.

    Eligible patients include those who currently have a diagnosis of high blood pressure, despite having taken or are currently taking anti-hypertensive medications.

     

    The "RADIANCE II" Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension

    The purpose of this clinical study is to see whether a medical device called the Paradise Renal Denervation System (also called The Paradise System) can lower high blood pressure in patients who are known to have hypertension

    Hypertension Research Team

    John M Flack

    John M. Flack, MD, MPH

    Bemi Adekola

    Oritsegbubemi Adekola, MD

    Priyanka Bhandari

    Priyanka Bhandari, MD

    Stephani

    Stephanie Bitner, PharmD

    Albert Botchway

    Albert Botchway, PhD

    Michael Buhnerkempe

    Michael Buhnerkempe, PhD

    Ashley Hill

    Ashley Hill, DNP