Trial
Internal Medicine

Mineralys (MLS-101-202): A RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, PARALLEL ARM, MULTI-CENTER, PHASE 2 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF LORUNDROSTAT IN SUBJECTS WITH UNCONTROLLED HYPERTENSION ON A STANDARDIZED MEDICATION REGIMEN

Active recruiting

The purpose of this clinical trial is to assess the blood pressure lowering effects of lorundrostat, taken once daily, in patients with high blood pressure.

Eligible patients include those who currently have a diagnosis of high blood pressure, despite having taken or are currently taking anti-hypertensive medications.

News

Providing hope, quality of life for those with Alzheimer’s

Art Express is one of many programs at the Smith Alzheimer’s Center at SIU Medicine designed to help those with dementia and their caregivers improve their quality of life.
News

Providing hope, quality of life for those with Alzheimer’s

Art Express is one of many programs at the Smith Alzheimer’s Center at SIU Medicine designed to help those with dementia and their caregivers improve their quality of life.
General Results

Hypertension Clinical Trials

Participate in a Clinical Trial The information you provide in the recruitment survey may be used to contact you if you qualify to participate in this study. Your information will be retained in a confidential, secure database. At any time, you can request to have your information removed from our database by contacting the SIU hypertension study team at 217-545-7511 or bpresearch@siumed.edu.
News

Finding the starting line for Alzheimer's

Where should research start in solving Alzheimer's? That's a tricky question to answer. What exactly are researchers looking for when trying to solve the Alzheimer’s puzzle? “It depends on the researcher,” says Kevin Hascup, PhD. “Really, the tried and true biomarkers are three — amyloid, tau and neurofilament light chain, or what is known as A/T/N.” A biomarker (molecules in blood, body fluid, and tissue) helps with understanding the changes that occur with age and disease onset. Each of the three A/T/N biomarkers progress in its own way in aging and with dementia. But no matter which
News

Get to know Aida Adlimoghaddam, PhD

Aida Adlimoghaddam, PhD, joins the Smith Alzheimer's Center in 2023 as an Assistant Professor. Most recently, she was the Senior Research Associate and Clinical Scientist at St. Boniface Hospital Research Centre in Winnipeg, Canada. What sparked your interest in research? As an undergraduate student, I developed a deep passion for biological sciences and discovered the vast array of research opportunities within the field. However, what truly fueled my interest in Alzheimer's research was a personal connection. My grandmother was diagnosed with Alzheimer's disease and endured several years of
News

Going on the offensive: The potential link between cell senescence and Alzheimer's

When you catch a cold or cut your finger, the immune system begins the healing process by clearing damaged cells. As we age, that process weakens. Health problems linger as immune systems aren’t quite as robust as they once were, whether it’s fighting bacteria, viruses, or cancer cells. Alzheimer’s researchers are now exploring a process called senescent cell accumulation to see if it could be detrimental.
Trial
Neuroscience Institute

Sleep for Stroke Management and Recovery Trial

Active recruiting

The primary goals of this study are to determine whether treatment of obstructive sleep apnea with positive airway pressure starting shortly after accute ischemic stroke or high risk TIA (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event and (2) improves stroke outcomes at 3 months in patients who experienced ischemic stroke.

Trial
Neuroscience Institute

18-513: A Randomized Clinical Trial of Andexanet Alfa in Acute Intracranial Hemorrhage in Patients Receiving an Oral Factor XA Inhibitor

Active not recruiting

18-513:  The purpose of this study is to evaluate the effect of andexanet alfa (andexanet) versus usual care on the rate of effective homostasis.

Trial
Urology

ProVIDE: The ProVee Urethral Expander System Study: The ProVee IDE Study

Active not recruiting

The study will test whether the study device, the ProVee Urethral Expander System, can be placed in your urethra safely to treat your urinary symptoms due to your enlarged prostate.

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